4R4I

Structure of RPA70N in complex with 5-(4-((6-(5-carboxyfuran-2-yl)-1-thioxo-3,4-dihydroisoquinolin-2(1H)-yl)methyl)phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid

Summary for 4R4I

Entry DOI	10.2210/pdb4r4i/pdb
Related	4R4C 4R4O 4R4Q 4R4T
Descriptor	Replication protein A 70 kDa DNA-binding subunit, 5-(4-{[6-(5-carboxyfuran-2-yl)-1-thioxo-3,4-dihydroisoquinolin-2(1H)-yl]methyl}phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid (3 entities in total)
Functional Keywords	ob-fold, protein-protein interaction, protein binding
Biological source	Homo sapiens (human)
Cellular location	Nucleus : P27694
Total number of polymer chains	1
Total formula weight	14116.21
Authors	Feldkamp, M.D.,Waterson, A.G.,Kennedy, J.P.,Patrone, J.D.,Pelz, N.F.,Frank, A.O.,Vangamudi, B.,Sousa-Fagundes, E.M.,Rossanese, O.W.,Fesik, S.W.,Chazin, W.J. (deposition date: 2014-08-19, release date: 2014-11-19, Last modification date: 2023-09-20)
Primary citation	Waterson, A.G.,Kennedy, J.P.,Patrone, J.D.,Pelz, N.F.,Feldkamp, M.D.,Frank, A.O.,Vangamudi, B.,Souza-Fagundes, E.M.,Rossanese, O.W.,Chazin, W.J.,Fesik, S.W. Diphenylpyrazoles as replication protein a inhibitors. ACS Med Chem Lett, 6:140-145, 2015 Cited by PubMed: 25699140 DOI: 10.1021/ml5003629 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation