4QXK
Joint X-ray/neutron structure of PKGIbeta in complex with cGMP
Summary for 4QXK
| Entry DOI | 10.2210/pdb4qxk/pdb |
| Descriptor | cGMP-dependent protein kinase 1, CYCLIC GUANOSINE MONOPHOSPHATE, SODIUM ION, ... (4 entities in total) |
| Functional Keywords | cyclic gmp (cgmp), type i cgmp dependent protein kinase (pkg i), cyclic nucleotide selectivity, serine/threonine protein kinase, signal transduction, second messengers, hydrogen bonding, solvent accessibility, signaling protein |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 17314.01 |
| Authors | Kim, C.,Gerlits, O.,Kovalevsky, A.,Huang, G.Y. (deposition date: 2014-07-21, release date: 2014-11-12, Last modification date: 2024-02-28) |
| Primary citation | Huang, G.Y.,Gerlits, O.O.,Blakeley, M.P.,Sankaran, B.,Kovalevsky, A.Y.,Kim, C. Neutron Diffraction Reveals Hydrogen Bonds Critical for cGMP-Selective Activation: Insights for cGMP-Dependent Protein Kinase Agonist Design. Biochemistry, 53:6725-6727, 2014 Cited by PubMed: 25271401DOI: 10.1021/bi501012v PDB entries with the same primary citation |
| Experimental method | NEUTRON DIFFRACTION (2.2 Å) X-RAY DIFFRACTION |
Structure validation
Download full validation report
