4QTB
Structure of human ERK1 in complex with SCH772984 revealing a novel inhibitor-induced binding pocket
Summary for 4QTB
Entry DOI | 10.2210/pdb4qtb/pdb |
Related | 4QTA 4QTC 4QTD 4QTE |
Descriptor | Mitogen-activated protein kinase 3, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ... (7 entities in total) |
Functional Keywords | structural genomics, structural genomics consortium, sgc, transferase, kinase, mapk, signalling, inhibitor, allosteric, structural genomics consortium (sgc), transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P27361 |
Total number of polymer chains | 2 |
Total formula weight | 89504.72 |
Authors | Chaikuad, A.,Keates, T.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2014-07-07, release date: 2014-07-23, Last modification date: 2023-09-20) |
Primary citation | Chaikuad, A.,M C Tacconi, E.,Zimmer, J.,Liang, Y.,Gray, N.S.,Tarsounas, M.,Knapp, S. A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics. Nat.Chem.Biol., 10:853-860, 2014 Cited by PubMed: 25195011DOI: 10.1038/nchembio.1629 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
Download full validation report