4QNZ

Crystal structure of rhomboid intramembrane protease GlpG F146I in complex with peptide derived inhibitor Ac-FATA-cmk

Summary for 4QNZ

Entry DOI	10.2210/pdb4qnz/pdb
Related PRD ID	PRD_001251
Descriptor	Rhomboid protease GlpG, ACE-PHE-ALA-THR-ALA-0QE, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	alpha-helical, rhomboid intramembrane protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Escherichia coli
Cellular location	Cell inner membrane; Multi-pass membrane protein (By similarity). Cell membrane; Multi-pass membrane protein (By similarity): U6NA71
Total number of polymer chains	2
Total formula weight	23512.71
Authors	Zoll, S.,Strisovsky, K. (deposition date: 2014-06-19, release date: 2014-09-24, Last modification date: 2023-09-20)
Primary citation	Zoll, S.,Stanchev, S.,Began, J.,Skerle, J.,Lepsik, M.,Peclinovska, L.,Majer, P.,Strisovsky, K. Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate-peptide complex structures. Embo J., 33:2408-2421, 2014 Cited by PubMed: 25216680 DOI: 10.15252/embj.201489367 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation