4QMV

MST3 IN COMPLEX WITH PF-03814735, N-{2-[(1S,4R)-6-{[4-(CYCLOBUTYLAMINO)-5-(TRIFLUOROMETHYL)PYRIMIDIN-2-YL]AMINO}-1,2,3,4-TETRAHYDRO-1,4-EPIMINONAPHTHALEN-9-YL]-2-OXOETHYL}ACETAMIDE

Summary for 4QMV

• Entry DOI: 10.2210/pdb4qmv/pdb
• Related: 4QML 4QMM 4QMN 4QMO 4QMP 4QMQ 4QMS 4QMT 4QMW 4QMX 4QMY 4QMZ 4QO9
• Descriptor: SERINE/THREONINE-PROTEIN KINASE 24, N-{2-[(1S,4R)-6-{[4-(cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-1,2,3,4-tetrahydro-1,4-epiminonaphthalen-9-yl]-2-oxoethyl}acetamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: protein kinase, mst3, stk24, sterile 20-like kinase, atp-binding, nucleotide-binding, phosphoprotein, serine/threonine-transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q9Y6E0
• Total number of polymer chains: 1
• Total formula weight: 35622.55

Authors

Olesen, S.H.,Watts, C.,Zhu, J.-Y.,Schonbrunn, E. (deposition date: 2014-06-16, release date: 2015-07-01, Last modification date: 2023-09-20)

• Primary citation: Olesen, S.H.,Zhu, J.Y.,Martin, M.P.,Schonbrunn, E.; Discovery of Diverse Small-Molecule Inhibitors of Mammalian Sterile20-like Kinase 3 (MST3).; Chemmedchem, 11:1137-1144, 2016; PubMed: 27135311; DOI: 10.1002/cmdc.201600115

Experimental method

X-RAY DIFFRACTION (2.4 Å)