4QIR

Crystal structure of Aminopeptidase N in complex with the phosphinic dipeptide analogue LL-(R,S)-2-(pyridin-3-yl)ethylGlyP[CH2]Phe

Summary for 4QIR

Entry DOI	10.2210/pdb4qir/pdb
Related	4PU2 4PVB 4PW4 4QHP 4QME 4QPE
Descriptor	Aminopeptidase N, 3-{[(R)-1-amino-3-(pyridin-3-yl)propyl](hydroxy)phosphoryl}-(S)-2-benzylpropanoic acid, GLYCEROL, ... (7 entities in total)
Functional Keywords	alanine aminopeptidase, aminopeptidase n, m1 family peptidases, 3-{[(r)-1-amino-3-(pyridin-3-yl)propyl](hydroxy)phosphoryl}-(s)-2-benzylpropanoic acid, hydrolase
Biological source	Neisseria meningitidis MC58
Total number of polymer chains	1
Total formula weight	100108.11
Authors	Nocek, B.,Joachimiak, A.,Berlicki, L.,Vassiliou, S.,Mucha, A. (deposition date: 2014-06-01, release date: 2014-09-24, Last modification date: 2023-12-06)
Primary citation	Vassiliou, S.,Weglarz-Tomczak, E.,Berlicki, L.,Paweczak, M.,Nocek, B.,Mulligan, R.,Joachimiak, A.,Mucha, A. Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases. J.Med.Chem., 57:8140-8151, 2014 Cited by PubMed: 25192493 DOI: 10.1021/jm501071f PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.701 Å)

Structure validation