4QIB

Oxidation-Mediated Inhibition of the Peptidyl-Prolyl Isomerase Pin1

Summary for 4QIB

• Entry DOI: 10.2210/pdb4qib/pdb
• Descriptor: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, SULFATE ION, ... (4 entities in total)
• Functional Keywords: cis-trans isomerization, oxidation of active site cysteine, cysteine sulfenic-sulfinic acid redox regulation, parvulin, isomerase
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q13526
• Total number of polymer chains: 1
• Total formula weight: 18379.24

Authors

Innes, B.T.,Sowole, M.A.,Konermann, L.,Litchfield, D.W.,Brandl, C.J.,Shilton, B.H. (deposition date: 2014-05-30, release date: 2015-02-04, Last modification date: 2015-03-04)

• Primary citation: Innes, B.T.,Sowole, M.A.,Gyenis, L.,Dubinsky, M.,Konermann, L.,Litchfield, D.W.,Brandl, C.J.,Shilton, B.H.; Peroxide-mediated oxidation and inhibition of the peptidyl-prolyl isomerase Pin1.; Biochim.Biophys.Acta, 1852:905-912, 2015; PubMed: 25595659; DOI: 10.1016/j.bbadis.2014.12.025

Experimental method

X-RAY DIFFRACTION (1.865 Å)