4QC6

Crystal structure of aminoglycoside 6'-acetyltransferase-Ie

Summary for 4QC6

Entry DOI	10.2210/pdb4qc6/pdb
Descriptor	Bifunctional AAC/APH, KANAMYCIN A, (3R,5S,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3,5-diphosphaheptadecane-17-sulfinic acid 3,5-dioxide (non-preferred name), ... (5 entities in total)
Functional Keywords	antibiotic resistance, gnat family, acetyltransferase, acetylcoenzyme-a, aminoglycoside, transferase, transferase-antibiotic complex, transferase/antibiotic
Biological source	Staphylococcus warneri
Cellular location	Cytoplasm : Q7ATH7
Total number of polymer chains	2
Total formula weight	46269.62
Authors	Smith, C.A.,Toth, M.,Weiss, T.M.,Frase, H.,Vakulenko, S.B. (deposition date: 2014-05-09, release date: 2014-10-22, Last modification date: 2024-02-28)
Primary citation	Smith, C.A.,Toth, M.,Weiss, T.M.,Frase, H.,Vakulenko, S.B. Structure of the bifunctional aminoglycoside-resistance enzyme AAC(6')-Ie-APH(2'')-Ia revealed by crystallographic and small-angle X-ray scattering analysis. Acta Crystallogr.,Sect.D, 70:2754-2764, 2014 Cited by PubMed: 25286858 DOI: 10.1107/S1399004714017635 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation