4QAF
Crystal structure of an engineered lipocalin (Anticalin) in complex with VEGF(8-109)
Summary for 4QAF
Entry DOI | 10.2210/pdb4qaf/pdb |
Descriptor | Lipocalin-1, Vascular endothelial growth factor A, 10-{(1R,2R)-2-[(2E)-hex-2-en-1-yl]cyclopropyl}decanoic acid, ... (6 entities in total) |
Functional Keywords | beta-barrel, binding protein, engineered lipocalin, transport protein-signaling protein complex, transport protein/signaling protein |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P31025 P15692 |
Total number of polymer chains | 4 |
Total formula weight | 59602.76 |
Authors | Giese, T.,Skerra, A. (deposition date: 2014-05-04, release date: 2015-05-06, Last modification date: 2023-09-20) |
Primary citation | Giese, T.,Skerra, A. Crystal structure of an Anticalin with specific blocking activity towards human vascular endothelial growth factor (VEGF) reveals plasticity of the lipocalin fold To be Published, |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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