4QA6

Crystal structure of I243N/Y306F HDAC8 in complex with a tetrapeptide substrate

Summary for 4QA6

Entry DOI	10.2210/pdb4qa6/pdb
Related	4QA0 4QA1 4QA2 4QA3 4QA4 4QA5 4QA7
Descriptor	Histone deacetylase 8, tetrapeptide substrate, ZINC ION, ... (7 entities in total)
Functional Keywords	metalloenzyme, hydrolase, histone deacetylase, enzyme substrate complex, cornelia de lange syndrome, arginase/deacetylase fold
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: Q9BY41
Total number of polymer chains	4
Total formula weight	88615.26
Authors	Decroos, C.,Bowman, C.B.,Moser, J.-A.S.,Christianson, K.E.,Deardorff, M.A.,Christianson, D.W. (deposition date: 2014-05-02, release date: 2014-08-06, Last modification date: 2023-12-06)
Primary citation	Decroos, C.,Bowman, C.M.,Moser, J.A.,Christianson, K.E.,Deardorff, M.A.,Christianson, D.W. Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol., 9:2157-2164, 2014 Cited by PubMed: 25075551 DOI: 10.1021/cb5003762 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.053 Å)

Structure validation