4PWQ

HIGH-RESOLUTION CRYSTAL STRUCTURE OF THE E1-DOMAIN of THE AMYLOID PRECURSOR PROTEIN

Summary for 4PWQ

• Entry DOI: 10.2210/pdb4pwq/pdb
• Descriptor: Amyloid beta A4 protein (2 entities in total)
• Functional Keywords: heparin binding, dimerization, heparin binding protein
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: P05067
• Total number of polymer chains: 2
• Total formula weight: 43524.16

Authors

Hoefgen, S.,Dahms, S.O.,Than, M.E. (deposition date: 2014-03-21, release date: 2015-02-04)

• Primary citation: Hoefgen, S.,Dahms, S.O.,Oertwig, K.,Than, M.E.; The Amyloid Precursor Protein Shows a pH-Dependent Conformational Switch in Its E1 Domain.; J.Mol.Biol., 427:433-442, 2015; PubMed: 25528641; DOI: 10.1016/j.jmb.2014.12.005

Experimental method

X-RAY DIFFRACTION (1.4 Å)