4P7E
Triazolopyridine compounds as selective JAK1 inhibitors: from hit identification to GLPG0634
Summary for 4P7E
Entry DOI | 10.2210/pdb4p7e/pdb |
Descriptor | Tyrosine-protein kinase JAK2, N-(5-{4-[(1,1-dioxidothiomorpholin-4-yl)methyl]phenyl}[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide (3 entities in total) |
Functional Keywords | transferase, jak1 inhibitor, triazolopyridine |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 70035.77 |
Authors | Menet, C.C.J.,Fletcher, S.,Van Lommen, G.,Geney, R.,Blanc, J.,Smits, K.,Jouannigot, N.,van der Aar, E.M.,Clement-Lacroix, P.,Lepescheux, L.,Galien, R.,Vayssiere, B.,Nelles, L.,Christophe, T.,Brys, R.,Uhring, M.,Ciesielski, F.,Van Rompaey, L. (deposition date: 2014-03-27, release date: 2014-11-19, Last modification date: 2023-12-20) |
Primary citation | Menet, C.J.,Fletcher, S.R.,Van Lommen, G.,Geney, R.,Blanc, J.,Smits, K.,Jouannigot, N.,Deprez, P.,van der Aar, E.M.,Clement-Lacroix, P.,Lepescheux, L.,Galien, R.,Vayssiere, B.,Nelles, L.,Christophe, T.,Brys, R.,Uhring, M.,Ciesielski, F.,Van Rompaey, L. Triazolopyridines as Selective JAK1 Inhibitors: From Hit Identification to GLPG0634. J.Med.Chem., 57:9323-9342, 2014 Cited by PubMed: 25369270DOI: 10.1021/jm501262q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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