4P4D
X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a phosphoramidate inhibitor MP1C
Summary for 4P4D
Entry DOI | 10.2210/pdb4p4d/pdb |
Descriptor | Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total) |
Functional Keywords | glutamate carboxypeptidase ii (gcpii), naaladase, prostate-specific membrane antigen, phosphoramidate, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 83246.22 |
Authors | Barinka, C. (deposition date: 2014-03-12, release date: 2015-05-20, Last modification date: 2020-07-29) |
Primary citation | Novakova, Z.,Cerny, J.,Choy, C.J.,Nedrow, J.R.,Choi, J.K.,Lubkowski, J.,Berkman, C.E.,Barinka, C. Design of composite inhibitors targeting glutamate carboxypeptidase II: the importance of effector functionalities. Febs J., 283:130-143, 2016 Cited by PubMed: 26460595DOI: 10.1111/febs.13557 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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