4P0X

Human farnesyl diphosphate synthase in complex with Taxodione

Summary for 4P0X

Entry DOI	10.2210/pdb4p0x/pdb
Descriptor	Farnesyl pyrophosphate synthase, (5beta)-11-hydroxyabieta-7,9(11),13-triene-6,12-dione (3 entities in total)
Functional Keywords	fpps, inhibitor, complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	40658.53
Authors	Liu, Y.L.,Oldfield, E. (deposition date: 2014-02-23, release date: 2014-07-02, Last modification date: 2023-12-27)
Primary citation	Liu, Y.L.,Lindert, S.,Zhu, W.,Wang, K.,McCammon, J.A.,Oldfield, E. Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site. Proc.Natl.Acad.Sci.USA, 111:E2530-E2539, 2014 Cited by PubMed: 24927548 DOI: 10.1073/pnas.1409061111 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation