4OQV

High resolution crystal structure of human dihydroorotate dehydrogenase bound with DSM338 (N-[3,5-difluoro-4-(trifluoromethyl)phenyl]-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine)

Summary for 4OQV

Entry DOI	10.2210/pdb4oqv/pdb
Related	4ORI 4ORM
Descriptor	Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (9 entities in total)
Functional Keywords	alpha/beta barrel, redox, dehydrogenase, fmn, mitochondrial membrane, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion inner membrane; Single-pass membrane protein: Q02127
Total number of polymer chains	1
Total formula weight	42487.79
Authors	Deng, X.,Phillips, M.A. (deposition date: 2014-02-10, release date: 2014-06-04, Last modification date: 2024-02-28)
Primary citation	Deng, X.,Kokkonda, S.,El Mazouni, F.,White, J.,Burrows, J.N.,Kaminsky, W.,Charman, S.A.,Matthews, D.,Rathod, P.K.,Phillips, M.A. Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors. J.Med.Chem., 57:5381-5394, 2014 Cited by PubMed: 24801997 DOI: 10.1021/jm500481t PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.23 Å)

Structure validation