4OJF
Humanised 3D6 Fab complexed to amyloid beta 1-8
Summary for 4OJF
Entry DOI | 10.2210/pdb4ojf/pdb |
Related | 4HIX |
Descriptor | Humanised 3D6 Fab Heavy Chain, Humanised 3D6 Fab Light Chain, Amyloid beta A4 protein, ... (4 entities in total) |
Functional Keywords | amyloid, bapineuzumab, 3d6, alzheimer's disease, immunoglobulin, immunotherapy, amyloid beta, immune system |
Biological source | Mus musculus (mouse) More |
Cellular location | Membrane; Single-pass type I membrane protein: P05067 |
Total number of polymer chains | 3 |
Total formula weight | 49274.90 |
Authors | Miles, L.A.,Crespi, G.A.N.,Parker, M.W. (deposition date: 2014-01-21, release date: 2015-01-28, Last modification date: 2023-11-08) |
Primary citation | Crespi, G.A.N.,Ascher, D.B.,Parker, M.W.,Miles, L.A. Crystallization and preliminary X-ray diffraction analysis of the Fab portion of the Alzheimer's disease immunotherapy candidate bapineuzumab complexed with amyloid-beta ACTA CRYSTALLOGR.,SECT.F, 70:374-377, 2014 Cited by PubMed: 24598931DOI: 10.1107/S2053230X14001642 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.998 Å) |
Structure validation
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