4OD0

Crystal structure of human soluble epoxide hydrolase complexed with 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea

Summary for 4OD0

Entry DOI	10.2210/pdb4od0/pdb
Related	4OCZ
Descriptor	Bifunctional epoxide hydrolase 2, PHOSPHATE ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	domain-swapped dimer, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P34913
Total number of polymer chains	1
Total formula weight	63164.24
Authors	Lee, K.S.S.,Liu, J.,Wagner, K.M.,Pakhomova, S.,Dong, H.,Morisseau, C.,Fu, S.H.,Yang, J.,Wang, P.,Ulu, A.,Mate, C.,Nguyen, L.,Wullf, H.,Eldin, M.L.,Mara, A.A.,Newcomer, M.E.,Zeldin, D.C.,Hammock, B.D. (deposition date: 2014-01-09, release date: 2014-09-24, Last modification date: 2023-09-20)
Primary citation	Lee, K.S.,Liu, J.Y.,Wagner, K.M.,Pakhomova, S.,Dong, H.,Morisseau, C.,Fu, S.H.,Yang, J.,Wang, P.,Ulu, A.,Mate, C.A.,Nguyen, L.V.,Hwang, S.H.,Edin, M.L.,Mara, A.A.,Wulff, H.,Newcomer, M.E.,Zeldin, D.C.,Hammock, B.D. Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy. J.Med.Chem., 57:7016-7030, 2014 Cited by PubMed: 25079952 DOI: 10.1021/jm500694p PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.92 Å)

Structure validation