4OAR

Progesterone receptor with bound ulipristal acetate and a peptide from the co-repressor SMRT

Summary for 4OAR

• Entry DOI: 10.2210/pdb4oar/pdb
• Descriptor: Progesterone receptor, Peptide from Nuclear receptor corepressor 2, [(8S,11R,13S,14S,17R)-17-acetyl-11-[4-(dimethylamino)phenyl]-13-methyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopen ta[a]phenanthren-17-yl] acetate, ... (4 entities in total)
• Functional Keywords: progesterone receptor, steroid receptor, nuclear receptor, transcription factor, women health, contraception, transcription-peptide complex, transcription/peptide
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus. Isoform A: Nucleus. Isoform 4: Mitochondrion outer membrane: P06401; Nucleus: Q9Y618
• Total number of polymer chains: 2
• Total formula weight: 32086.73

Authors

Petit-Topin, I.,Fay, M.R.,Resche-Rigon, M.,Ulmann, A.,Gainer, E.,Rafestin-Oblin, M.-E.,Fagart, J. (deposition date: 2014-01-06, release date: 2014-10-08, Last modification date: 2023-09-20)

• Primary citation: Petit-Topin, I.,Fay, M.,Resche-Rigon, M.,Ulmann, A.,Gainer, E.,Rafestin-Oblin, M.E.,Fagart, J.; Molecular determinants of the recognition of ulipristal acetate by oxo-steroid receptors.; J.Steroid Biochem.Mol.Biol., 144PB:427-435, 2014; PubMed: 25204619; DOI: 10.1016/j.jsbmb.2014.08.008

Experimental method

X-RAY DIFFRACTION (2.41 Å)