4NYA

Crystal structure of the E. coli thiM riboswitch in complex with 5-(azidomethyl)-2-methylpyrimidin-4-amine

Summary for 4NYA

• Entry DOI: 10.2210/pdb4nya/pdb
• Related: 4NYB 4NYC 4NYD 4NYG
• Descriptor: thiM TPP riboswitch, MAGNESIUM ION, 5-(azidomethyl)-2-methylpyrimidin-4-amine, ... (4 entities in total)
• Functional Keywords: fragment-based drug discovery, riboswitch, rna
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 52777.41

Authors

Warner, K.D.,Homan, P.,Weeks, K.M.,Smith, A.G.,Abell, C.,Ferre-D'Amare, A.R. (deposition date: 2013-12-10, release date: 2014-06-04, Last modification date: 2023-09-20)

• Primary citation: Warner, K.D.,Homan, P.,Weeks, K.M.,Smith, A.G.,Abell, C.,Ferre-D'Amare, A.R.; Validating Fragment-Based Drug Discovery for Biological RNAs: Lead Fragments Bind and Remodel the TPP Riboswitch Specifically.; Chem.Biol., 21:591-595, 2014; PubMed: 24768306; DOI: 10.1016/j.chembiol.2014.03.007

Experimental method

X-RAY DIFFRACTION (2.65 Å)