4NRA

Crystal Structure of the bromodomain of human BAZ2B in complex with compound-6 E11322

Summary for 4NRA

Entry DOI	10.2210/pdb4nra/pdb
Related	4NR9 4NRB 4NRC
Descriptor	Bromodomain adjacent to zinc finger domain protein 2B, 1,2-ETHANEDIOL, 1-(8-chloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)ethanone, ... (4 entities in total)
Functional Keywords	sgc, structural genomics consortium, transcription, bromodomain, acetylated lysine binding protein, kiaa1476, walp4
Biological source	Homo sapiens (human)
Cellular location	Nucleus (Potential): Q9UIF8
Total number of polymer chains	1
Total formula weight	14177.70
Authors	Chaikuad, A.,Felletar, I.,Ferguson, F.M.,Filippakopoulos, P.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2013-11-26, release date: 2013-12-25, Last modification date: 2023-09-20)
Primary citation	Ferguson, F.M.,Fedorov, O.,Chaikuad, A.,Philpott, M.,Muniz, J.R.,Felletar, I.,von Delft, F.,Heightman, T.,Knapp, S.,Abell, C.,Ciulli, A. Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain. J.Med.Chem., 56:10183-10187, 2013 Cited by PubMed: 24304323 DOI: 10.1021/jm401582c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation