4NQU

anti-parallel Fc-knob (T366W) homodimer

Summary for 4NQU

Entry DOI	10.2210/pdb4nqu/pdb
Related	4NQS 4NQT
Descriptor	Ig gamma-1 chain C region, SULFATE ION (3 entities in total)
Functional Keywords	immunoglobulin, immune system
Biological source	Homo sapiens (human)
Cellular location	Secreted: P01857
Total number of polymer chains	1
Total formula weight	24301.46
Authors	Eigenbrot, C.,Ultsch, M. (deposition date: 2013-11-25, release date: 2014-03-12, Last modification date: 2023-09-20)
Primary citation	Elliott, J.M.,Ultsch, M.,Lee, J.,Tong, R.,Takeda, K.,Spiess, C.,Eigenbrot, C.,Scheer, J.M. Antiparallel Conformation of Knob and Hole Aglycosylated Half-Antibody Homodimers Is Mediated by a CH2-CH3 Hydrophobic Interaction. J.Mol.Biol., 426:1947-1957, 2014 Cited by PubMed: 24576605 DOI: 10.1016/j.jmb.2014.02.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation