4NPU

Crystal Structure of HIV-1 Protease Multiple Mutant P51

Summary for 4NPU

• Entry DOI: 10.2210/pdb4npu/pdb
• Related: 4NPT
• Descriptor: Protease (2 entities in total)
• Functional Keywords: hiv-1 protease, p51, multiple mutant, drug resistance, hydrolase
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 2
• Total formula weight: 21569.25

Authors

Zhang, Y.,Weber, I.T. (deposition date: 2013-11-22, release date: 2014-10-08, Last modification date: 2023-09-20)

• Primary citation: Zhang, Y.,Chang, Y.C.,Louis, J.M.,Wang, Y.F.,Harrison, R.W.,Weber, I.T.; Structures of darunavir-resistant HIV-1 protease mutant reveal atypical binding of darunavir to wide open flaps.; Acs Chem.Biol., 9:1351-1358, 2014; PubMed: 24738918; DOI: 10.1021/cb4008875

Experimental method

X-RAY DIFFRACTION (1.5 Å)