4NP8

Structure of an amyloid forming peptide VQIVYK from the second repeat region of tau (alternate polymorph)

Replaces:  3FQP

Summary for 4NP8

• Entry DOI: 10.2210/pdb4np8/pdb
• Related: 2ON9 3OVL
• Descriptor: Microtubule-associated protein tau (2 entities in total)
• Functional Keywords: amyloid-like protofibril, protein fibril
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm, cytosol: P10636
• Total number of polymer chains: 1
• Total formula weight: 749.92

Authors

Landau, M.,Eisenberg, D.,Sawaya, M.R.,Dannenberg, J.,Kobko, N. (deposition date: 2013-11-20, release date: 2013-12-18, Last modification date: 2023-09-20)

• Primary citation: Wiltzius, J.J.,Landau, M.,Nelson, R.,Sawaya, M.R.,Apostol, M.I.,Goldschmidt, L.,Soriaga, A.B.,Cascio, D.,Rajashankar, K.,Eisenberg, D.; Molecular mechanisms for protein-encoded inheritance.; Nat.Struct.Mol.Biol., 16:973-978, 2009; PubMed: 19684598; DOI: 10.1038/nsmb.1643

Experimental method

X-RAY DIFFRACTION (1.51 Å)