4NIV

Crystal structure of trypsiligase (K60E/N143H/Y151H/D189K trypsin) trigonal form

Summary for 4NIV

Entry DOI	10.2210/pdb4niv/pdb
Related	4NIW 4NIX 4NIY
Descriptor	Cationic trypsin, CALCIUM ION, GLYCEROL, ... (4 entities in total)
Functional Keywords	trypsin, serine proteinase, enzyme design, activation domain, zymogen, peptide ligation, reverse proteolysis, hydrolase
Biological source	Bos taurus (bovine,cow,domestic cattle,domestic cow)
Cellular location	Secreted, extracellular space: P00760
Total number of polymer chains	1
Total formula weight	23469.50
Authors	Schoepfel, M.,Parthier, C.,Stubbs, M.T. (deposition date: 2013-11-08, release date: 2014-02-19, Last modification date: 2014-03-19)
Primary citation	Liebscher, S.,Schopfel, M.,Aumuller, T.,Sharkhuukhen, A.,Pech, A.,Hoss, E.,Parthier, C.,Jahreis, G.,Stubbs, M.T.,Bordusa, F. N-terminal protein modification by substrate-activated reverse proteolysis. Angew.Chem.Int.Ed.Engl., 53:3024-3028, 2014 Cited by PubMed: 24520050 DOI: 10.1002/anie.201307736 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1 Å)

Structure validation