4NIE
Crystal structure of the orphan nuclear receptor ROR(gamma)t ligand-binding domain in complex with small molecule ligand
Summary for 4NIE
Entry DOI | 10.2210/pdb4nie/pdb |
Descriptor | Nuclear receptor ROR-gamma, Peptide from Nuclear receptor coactivator 2, N-(4-{[benzyl(propyl)amino]methyl}phenyl)-2-[4-(ethylsulfonyl)phenyl]acetamide, ... (5 entities in total) |
Functional Keywords | nuclear receptor, ligand binding domain, transcription-agonist complex, transcription/agonist |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 65684.45 |
Authors | Ma, Y.L.,Yang, L.Q. (deposition date: 2013-11-06, release date: 2013-12-11, Last modification date: 2024-03-20) |
Primary citation | Yang, T.,Liu, Q.,Cheng, Y.,Cai, W.,Ma, Y.,Yang, L.,Wu, Q.,Orband-Miller, L.A.,Zhou, L.,Xiang, Z.,Huxdorf, M.,Zhang, W.,Zhang, J.,Xiang, J.N.,Leung, S.,Qiu, Y.,Zhong, Z.,Elliott, J.D.,Lin, X.,Wang, Y. Discovery of Tertiary Amine and Indole Derivatives as Potent ROR gamma t Inverse Agonists. Acs Med.Chem.Lett., 5:65-68, 2014 Cited by PubMed: 24900774DOI: 10.1021/ml4003875 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.01 Å) |
Structure validation
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