4NBP

Crystal structure of the JCV large T-antigen origin binding domain

Summary for 4NBP

Entry DOI	10.2210/pdb4nbp/pdb
Related	4LIF 4LMD
Descriptor	Large T antigen, L(+)-TARTARIC ACID (3 entities in total)
Functional Keywords	origin binding domain, dna replication, binds dna, hydrolase
Biological source	JC polyomavirus (JCPyV)
Cellular location	Host nucleus (By similarity): P03072
Total number of polymer chains	1
Total formula weight	15470.56
Authors	Meinke, G.,Bohm, A.,Bullock, P. (deposition date: 2013-10-23, release date: 2014-03-05, Last modification date: 2014-04-02)
Primary citation	Meinke, G.,Phelan, P.J.,Kalekar, R.,Shin, J.,Archambault, J.,Bohm, A.,Bullock, P.A. Insights into the Initiation of JC Virus DNA Replication Derived from the Crystal Structure of the T-Antigen Origin Binding Domain. Plos Pathog., 10:e1003966-e1003966, 2014 Cited by PubMed: 24586168 DOI: 10.1371/journal.ppat.1003966 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.315 Å)

Structure validation