4NAH

Inhibitors of 4-Phosphopanthetheine Adenylyltransferase (PPAT)

Summary for 4NAH

• Entry DOI: 10.2210/pdb4nah/pdb
• Related: 4NAT 4NAU
• Descriptor: Phosphopantetheine adenylyltransferase, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, 2-[(2-{(1S,2S)-2-[(3,4-dichlorobenzyl)carbamoyl]cyclohexyl}-6-ethylpyrimidin-4-yl)sulfanyl]-1H-imidazole-5-carboxylic acid, ... (4 entities in total)
• Functional Keywords: phosphopanthetheine adenylyltransferase, phosphopanthetheine, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Staphylococcus aureus
• Cellular location: Cytoplasm (By similarity): P63820
• Total number of polymer chains: 6
• Total formula weight: 116729.17

Authors

Lahiri, S.D. (deposition date: 2013-10-22, release date: 2014-03-12, Last modification date: 2024-02-28)

• Primary citation: de Jonge, B.L.,Walkup, G.K.,Lahiri, S.D.,Huynh, H.,Neckermann, G.,Utley, L.,Nash, T.J.,Brock, J.,San Martin, M.,Kutschke, A.,Johnstone, M.,Laganas, V.,Hajec, L.,Gu, R.F.,Ni, H.,Chen, B.,Hutchings, K.,Holt, E.,McKinney, D.,Gao, N.,Livchak, S.,Thresher, J.; Discovery of inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) to validate PPAT as a target for antibacterial therapy.; Antimicrob.Agents Chemother., 57:6005-6015, 2013; PubMed: 24041904; DOI: 10.1128/AAC.01661-13

Experimental method

X-RAY DIFFRACTION (2.38 Å)