4N9E
Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
Summary for 4N9E
Entry DOI | 10.2210/pdb4n9e/pdb |
Related | 4N9B 4N9C 4N9D |
Descriptor | Nicotinamide phosphoribosyltransferase, 1-[(1-benzoylpiperidin-4-yl)methyl]-N-(pyridin-3-yl)-1H-benzimidazole-5-carboxamide, PHOSPHATE ION, ... (6 entities in total) |
Functional Keywords | transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P43490 |
Total number of polymer chains | 2 |
Total formula weight | 116503.57 |
Authors | Dragovich, P.S.,Zhao, G.,Baumeister, T.,Bravo, B.,Giannetti, A.M.,Ho, Y.,Hua, R.,Li, G.,Liang, X.,O'Brien, T.,Skelton, N.J.,Wang, C.,Zhao, Q.,Oh, A.,Wang, W.,Wang, Y.,Xiao, Y.,Yuen, P.,Zak, M.,Zheng, X. (deposition date: 2013-10-20, release date: 2014-02-19, Last modification date: 2024-02-28) |
Primary citation | Dragovich, P.S.,Zhao, G.,Baumeister, T.,Bravo, B.,Giannetti, A.M.,Ho, Y.C.,Hua, R.,Li, G.,Liang, X.,Ma, X.,O'Brien, T.,Oh, A.,Skelton, N.J.,Wang, C.,Wang, W.,Wang, Y.,Xiao, Y.,Yuen, P.W.,Zak, M.,Zhao, Q.,Zheng, X. Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 24:954-962, 2014 Cited by PubMed: 24433859DOI: 10.1016/j.bmcl.2013.12.062 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.72 Å) |
Structure validation
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