4N07

Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM-344 at 1.87 A resolution

Summary for 4N07

• Entry DOI: 10.2210/pdb4n07/pdb
• Related: 3tdj
• Descriptor: Glutamate receptor 2, 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, GLUTAMIC ACID, ... (8 entities in total)
• Functional Keywords: ampa receptor ligand-binding domain, glua2 s1s2j-l483y-n754s, bpam-344 allosteric modulation, membrane protein
• Biological source: Rattus norvegicus (rat); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P19491
• Total number of polymer chains: 3
• Total formula weight: 91013.45

Authors

Noerholm, A.B.,Frydenvang, K.,Kastrup, J.S. (deposition date: 2013-10-01, release date: 2013-11-20, Last modification date: 2023-09-20)

• Primary citation: Nrholm, A.B.,Francotte, P.,Olsen, L.,Krintel, C.,Frydenvang, K.,Goffin, E.,Challal, S.,Danober, L.,Botez-Pop, I.,Lestage, P.,Pirotte, B.,Kastrup, J.S.; Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold.; J.Med.Chem., 56:8736-8745, 2013; PubMed: 24131202; DOI: 10.1021/jm4012092

Experimental method

X-RAY DIFFRACTION (1.87 Å)