4MXY
Src M314L T338M double mutant bound to kinase inhibitor bosutinib
Summary for 4MXY
Entry DOI | 10.2210/pdb4mxy/pdb |
Related | 4MXO 4MXX 4MXZ |
Descriptor | Proto-oncogene tyrosine-protein kinase Src, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile (3 entities in total) |
Functional Keywords | kinase, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane: P12931 |
Total number of polymer chains | 2 |
Total formula weight | 66506.17 |
Authors | Levinson, N.M.,Boxer, S.G. (deposition date: 2013-09-26, release date: 2013-12-25, Last modification date: 2024-02-28) |
Primary citation | Levinson, N.M.,Boxer, S.G. A conserved water-mediated hydrogen bond network defines bosutinib's kinase selectivity. Nat.Chem.Biol., 10:127-132, 2014 Cited by PubMed: 24292070DOI: 10.1038/nchembio.1404 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.582 Å) |
Structure validation
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