4MUI

Crystal structure of pantothenate synthetase in complex with 2-(5-methoxy-2-(4-methoxyphenylsulfonylcarbamoyl)-1H-indol-1-yl)acetic acid

Summary for 4MUI

Entry DOI	10.2210/pdb4mui/pdb
Related	4MQ6 4MUE 4MUF 4MUG 4MUH
Descriptor	Pantothenate synthetase, ETHANOL, (5-methoxy-2-{[(4-methoxyphenyl)sulfonyl]carbamoyl}-1H-indol-1-yl)acetic acid, ... (5 entities in total)
Functional Keywords	alpha beta 3-layer(aba) sandwich rossmann fold, pantoate-ligase, atp binding, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	2
Total formula weight	64672.00
Authors	Silvestre, H.L.,Blundell, T.L. (deposition date: 2013-09-22, release date: 2014-08-27, Last modification date: 2023-09-20)
Primary citation	Hung, A.W.,Silvestre, H.L.,Wen, S.,George, G.P.,Boland, J.,Blundell, T.L.,Ciulli, A.,Abell, C. Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis. Chemmedchem, 11:38-42, 2016 Cited by PubMed: 26486566 DOI: 10.1002/cmdc.201500414 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation