4MO8

The crystal structure of the human carbonic anhydrase II in complex with N-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]sulfamide

Summary for 4MO8

Entry DOI	10.2210/pdb4mo8/pdb
Related	4L84
Descriptor	Carbonic anhydrase 2, ZINC ION, N-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]sulfamide, ... (4 entities in total)
Functional Keywords	sulfamide, zinc binding, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P00918
Total number of polymer chains	1
Total formula weight	29603.72
Authors	Alterio, V.,De Simone, G. (deposition date: 2013-09-11, release date: 2013-10-30, Last modification date: 2023-09-20)
Primary citation	Rami, M.,Dubois, L.,Parvathaneni, N.K.,Alterio, V.,van Kuijk, S.J.,Monti, S.M.,Lambin, P.,De Simone, G.,Supuran, C.T.,Winum, J.Y. Hypoxia-Targeting Carbonic Anhydrase IX Inhibitors by a New Series of Nitroimidazole-Sulfonamides/Sulfamides/Sulfamates. J.Med.Chem., 56:8512-8520, 2013 Cited by PubMed: 24128000 DOI: 10.1021/jm4009532 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation