4MI8

Crystal structure of the complex of murine gamma-herpesvirus 68 Bcl-2 homolog M11 and a Beclin 1 BH3 domain-derived peptide

Summary for 4MI8

• Entry DOI: 10.2210/pdb4mi8/pdb
• Related: 3DVU
• Descriptor: Bcl-2 homolog (Gene 16?), Beclin-1, SULFATE ION, ... (4 entities in total)
• Functional Keywords: bh3d, bcl-2 family, anti-apoptotic and anti-autophagic activities, viral protein-apoptosis complex, viral protein/apoptosis
• Biological source: Murid herpesvirus 4 (MuHV-4); More
• Cellular location: Cytoplasm . Beclin-1-C 35 kDa: Mitochondrion . Beclin-1-C 37 kDa: Mitochondrion : Q14457
• Total number of polymer chains: 4
• Total formula weight: 39380.49

Authors

Su, M.,Mei, Y.,Sinha, S. (deposition date: 2013-08-30, release date: 2014-01-29, Last modification date: 2016-02-17)

• Primary citation: Su, M.,Mei, Y.,Sanishvili, R.,Levine, B.,Colbert, C.L.,Sinha, S.; Targeting gamma-herpesvirus 68 Bcl-2-mediated down-regulation of autophagy.; J.Biol.Chem., 289:8029-8040, 2014; PubMed: 24443581; DOI: 10.1074/jbc.M113.515361

Experimental method

X-RAY DIFFRACTION (2.1 Å)