4MDD
Crystal Structure of the Glucocorticoid Receptor Bound to a Non-steroidal Antagonist Reveals Repositioning and Partial Disordering of Activation Function Helix 12
Summary for 4MDD
Entry DOI | 10.2210/pdb4mdd/pdb |
Descriptor | Glucocorticoid receptor, Nuclear receptor corepressor 1, N-[2-{[benzyl(methyl)amino]methyl}-3-(4-fluoro-2-methoxyphenyl)-5-(propan-2-yl)-1H-indol-7-yl]methanesulfonamide, ... (4 entities in total) |
Functional Keywords | nuclear hormone receptor ligand binding domain, protein binding |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm. Isoform Beta: Nucleus: P04150 Nucleus : O75376 |
Total number of polymer chains | 4 |
Total formula weight | 63617.76 |
Authors | Coghlan, M.J.,Luz, J.G. (deposition date: 2013-08-22, release date: 2014-12-03, Last modification date: 2024-02-28) |
Primary citation | Luz, J.G.,Coghlan, M.J. Crystal Structure of the Glucocorticoid Receptor Bound to a Non-steroidal Antagonist Reveals Repositioning and Partial Disordering of Activation Function Helix 12 To be Published, |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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