4MBJ

Human B-Raf Kinase Domain in Complex with an Imidazopyridine-based Inhibitor

Summary for 4MBJ

Entry DOI	10.2210/pdb4mbj/pdb
Descriptor	Serine/threonine-protein kinase B-raf, 2,6-difluoro-N-(1H-imidazo[4,5-b]pyridin-6-yl)-3-[(propylsulfonyl)amino]benzamide (2 entities in total)
Functional Keywords	kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus (By similarity): P15056
Total number of polymer chains	2
Total formula weight	70409.04
Authors	Voegtli, W.C. (deposition date: 2013-08-19, release date: 2013-10-02, Last modification date: 2024-02-28)
Primary citation	Newhouse, B.J.,Wenglowsky, S.,Grina, J.,Laird, E.R.,Voegtli, W.C.,Ren, L.,Ahrendt, K.,Buckmelter, A.,Gloor, S.L.,Klopfenstein, N.,Rudolph, J.,Wen, Z.,Li, X.,Feng, B. Imidazo[4,5-b]pyridine inhibitors of B-Raf kinase. Bioorg.Med.Chem.Lett., 23:5896-5899, 2013 Cited by PubMed: 24042006 DOI: 10.1016/j.bmcl.2013.08.086 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.6 Å)

Structure validation