4M7V

Dihydrofolate reductase from Enterococcus faecalis complexed with NADP(H)and RAB-propyl

Summary for 4M7V

• Entry DOI: 10.2210/pdb4m7v/pdb
• Related: 4M7U
• Descriptor: Dihydrofolate reductase, 5-(3,4-dimethoxy-5-{(1E)-3-oxo-3-[(1S)-1-propylphthalazin-2(1H)-yl]prop-1-en-1-yl}benzyl)pyrimidine-2,4-diamine, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• Functional Keywords: oxidoreductase, reduction of dihydrofolate to tetrahydrofolate
• Biological source: Enterococcus faecalis
• Total number of polymer chains: 1
• Total formula weight: 21146.59

Authors

Bourne, C.R. (deposition date: 2013-08-12, release date: 2014-03-05, Last modification date: 2023-09-20)

• Primary citation: Bourne, C.R.,Wakeham, N.,Webb, N.,Nammalwar, B.,Bunce, R.A.,Berlin, K.D.,Barrow, W.W.; The Structure and Competitive Substrate Inhibition of Dihydrofolate Reductase from Enterococcus faecalis Reveal Restrictions to Cofactor Docking.; Biochemistry, 53:1228-1238, 2014; PubMed: 24495113; DOI: 10.1021/bi401104t

Experimental method

X-RAY DIFFRACTION (2.3 Å)