4LVY
Structure of the THF riboswitch bound to pemetrexed
Summary for 4LVY
Entry DOI | 10.2210/pdb4lvy/pdb |
Related | 3SD3 4LVV 4LVW 4LVY 4LVZ 4LW0 |
Descriptor | THF riboswitch, 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID (3 entities in total) |
Functional Keywords | aptamers, nucleotide, bacillus subtilis, bacterial proteins, base sequence, binding sites, calorimetry, folic acid, gene expression regulation, bacterial, guanine, leucovorin, ligands, magnesium, molecular sequence data, nucleic acid conformation, point mutation, protein binding, protein structure, secondary, rna, riboswitch, s-adenosylmethionine, streptococcus mutans, terminator regions, genetic, tetrahydrofolates, thermodynamics, transcription, three-way junction, pseudoknot, regulation, ncrna, pemetrexed binding, mrna |
Total number of polymer chains | 1 |
Total formula weight | 29703.97 |
Authors | Trausch, J.J.,Batey, R.T. (deposition date: 2013-07-26, release date: 2014-03-19, Last modification date: 2024-02-28) |
Primary citation | Trausch, J.J.,Batey, R.T. A Disconnect between High-Affinity Binding and Efficient Regulation by Antifolates and Purines in the Tetrahydrofolate Riboswitch. Chem.Biol., 21:205-216, 2014 Cited by PubMed: 24388757DOI: 10.1016/j.chembiol.2013.11.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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