4LNG

Aspergillus fumigatus protein farnesyltransferase complex with farnesyldiphosphate and tipifarnib

Summary for 4LNG

Entry DOI	10.2210/pdb4lng/pdb
Related	4L9P 4LNB
Descriptor	CaaX farnesyltransferase alpha subunit Ram2, CaaX farnesyltransferase beta subunit Ram1, 1,2-ETHANEDIOL, ... (8 entities in total)
Functional Keywords	farnesyltransferase, prenylation, isoprenoid and caax-containing protein and peptide substrates, farnesylation, transferase
Biological source	Aspergillus fumigatus More
Total number of polymer chains	2
Total formula weight	100313.83
Authors	Mabanglo, M.F.,Hast, M.A.,Beese, L.S. (deposition date: 2013-07-11, release date: 2014-01-01, Last modification date: 2024-02-28)
Primary citation	Mabanglo, M.F.,Hast, M.A.,Lubock, N.B.,Hellinga, H.W.,Beese, L.S. Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design. Protein Sci., 23:289-301, 2014 Cited by PubMed: 24347326 DOI: 10.1002/pro.2411 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.905 Å)

Structure validation