4LL0
EGFR L858R/T790M in complex with PD168393
Summary for 4LL0
Entry DOI | 10.2210/pdb4ll0/pdb |
Related | 4LRM |
Descriptor | Epidermal growth factor receptor, N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide (2 entities in total) |
Functional Keywords | kinase, pd168393, 34-jab, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 2 |
Total formula weight | 76155.62 |
Authors | |
Primary citation | Red Brewer, M.,Yun, C.H.,Lai, D.,Lemmon, M.A.,Eck, M.J.,Pao, W. Mechanism for activation of mutated epidermal growth factor receptors in lung cancer. Proc.Natl.Acad.Sci.USA, 110:E3595-E3604, 2013 Cited by PubMed: 24019492DOI: 10.1073/pnas.1220050110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (4 Å) |
Structure validation
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