4LK3

Crystal structure of Human UDP-xylose synthase R236A substitution

Summary for 4LK3

Entry DOI	10.2210/pdb4lk3/pdb
Descriptor	UDP-glucuronic acid decarboxylase 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, URIDINE-5'-DIPHOSPHATE, ... (7 entities in total)
Functional Keywords	short-chain dehydrogenase/reductase, decarboxylase, lyase, membrane, rossmann fold
Biological source	Homo sapiens (human)
Cellular location	Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein : Q8NBZ7
Total number of polymer chains	6
Total formula weight	237095.54
Authors	Walsh Jr., R.M.,Polizzi, S.J.,Wood, Z.A. (deposition date: 2013-07-05, release date: 2013-08-07, Last modification date: 2023-09-20)
Primary citation	Walsh Jr., R.M.,Polizzi, S.J.,Kadirvelraj, R.,Howard, W.W.,Wood, Z.A. Man o' war mutation in UDP-alpha-D-xylose synthase favors the abortive catalytic cycle and uncovers a latent potential for hexamer formation. Biochemistry, 54:807-819, 2015 Cited by PubMed: 25521717 DOI: 10.1021/bi501357c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.64 Å)

Structure validation