4LI5
EGFR-K IN COMPLEX WITH N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxy-phenyl] Prop-2-enamide
Summary for 4LI5
Entry DOI | 10.2210/pdb4li5/pdb |
Descriptor | Epidermal growth factor receptor, N-(3-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-4-methoxyphenyl)propanamide, SODIUM ION, ... (4 entities in total) |
Functional Keywords | egf receptor kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 1 |
Total formula weight | 37839.15 |
Authors | Debreczeni, J.E.,Seiffert, G.B.,Kiefersauer, R.,Augustin, M.,Nagel, S.,Ward, R.,Anderton, M.,Ashton, S.,Bethel, P.,Box, M.,Butterworth, S.,Colclough, N.,Chroley, C.,Chuaqui, C.,Cross, D.,Eberlein, C.,Finlay, R.,Hill, G.,Grist, M.,Klinowska, T.,Lane, C.,Martin, S.,Orme, J.,Smith, P.,Wang, F.,Waring, M. (deposition date: 2013-07-02, release date: 2013-08-28, Last modification date: 2024-02-28) |
Primary citation | Ward, R.A.,Anderton, M.J.,Ashton, S.,Bethel, P.A.,Box, M.,Butterworth, S.,Colclough, N.,Chorley, C.G.,Chuaqui, C.,Cross, D.A.,Dakin, L.A.,Debreczeni, J.E.,Eberlein, C.,Finlay, M.R.,Hill, G.B.,Grist, M.,Klinowska, T.C.,Lane, C.,Martin, S.,Orme, J.P.,Smith, P.,Wang, F.,Waring, M.J. Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR). J.Med.Chem., 56:7025-7048, 2013 Cited by PubMed: 23930994DOI: 10.1021/jm400822z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.64 Å) |
Structure validation
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