4LD5

Crystal structure of MepR Q18P mutant from multidrug resistant S. aureus clinical isolate

Summary for 4LD5

• Entry DOI: 10.2210/pdb4ld5/pdb
• Related: 4L9J 4L9N 4L9T 4L9V
• Descriptor: MepR, SULFATE ION (3 entities in total)
• Functional Keywords: multidrug resistance, winged helix-turn-helix, transcription repression, transcription
• Biological source: Staphylococcus aureus
• Total number of polymer chains: 8
• Total formula weight: 136593.80

Authors

Birukou, I.,Brennan, R.G. (deposition date: 2013-06-24, release date: 2013-09-11, Last modification date: 2024-02-28)

• Primary citation: Birukou, I.,Tonthat, N.K.,Seo, S.M.,Schindler, B.D.,Kaatz, G.W.,Brennan, R.G.; The molecular mechanisms of allosteric mutations impairing MepR repressor function in multidrug-resistant strains of Staphylococcus aureus.; MBio, 4:e00528-e00513, 2013; PubMed: 23982071; DOI: 10.1128/mBio.00528-13

Experimental method

X-RAY DIFFRACTION (2.4 Å)