4L7F

Co-crystal Structure of JNK1 and AX13587

Summary for 4L7F

Entry DOI	10.2210/pdb4l7f/pdb
Descriptor	Mitogen-activated protein kinase 8, N-[1-(4-fluorophenyl)cyclopropyl]-4-[(trans-4-hydroxycyclohexyl)amino]imidazo[1,2-a]quinoxaline-8-carboxamide (3 entities in total)
Functional Keywords	protein kinase fold, protein kinase, jun-c, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P45983
Total number of polymer chains	1
Total formula weight	42836.62
Authors	Walter, R.L.,Ranieri, G.M.,Riggs, A.M.,Weissig, H.,Li, B.,Shreder, K.R. (deposition date: 2013-06-13, release date: 2013-08-21, Last modification date: 2024-02-28)
Primary citation	Li, B.,Cociorva, O.M.,Nomanbhoy, T.,Weissig, H.,Li, Q.,Nakamura, K.,Liyanage, M.,Zhang, M.C.,Shih, A.Y.,Aban, A.,Hu, Y.,Cajica, J.,Pham, L.,Kozarich, J.W.,Shreder, K.R. Hit-to-lead optimization and kinase selectivity of imidazo[1,2-a]quinoxalin-4-amine derived JNK1 inhibitors. Bioorg.Med.Chem.Lett., 23:5217-5222, 2013 Cited by PubMed: 23916259 DOI: 10.1016/j.bmcl.2013.06.087 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation