4L7C
Structure of keap1 kelch domain with 2-{[(1S)-2-{[(1R,2S)-2-(1H-tetrazol-5-yl)cyclohexyl]carbonyl}-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-1H-isoindole-1,3(2H)-dione
Summary for 4L7C
Entry DOI | 10.2210/pdb4l7c/pdb |
Related | 4L7C 4L7D 4N1B |
Descriptor | Kelch-like ECH-associated protein 1, 2-{[(1S)-2-{[(1R,2S)-2-(1H-tetrazol-5-yl)cyclohexyl]carbonyl}-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-1H-isoindole-1,3(2H)-dione, ACETATE ION, ... (4 entities in total) |
Functional Keywords | stress sensor, kelch domain, kelch repeat motif, beta-propeller, nrf2, protein-small molecule complex, transcription-inhibitor complex, transcription/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q14145 |
Total number of polymer chains | 3 |
Total formula weight | 100736.19 |
Authors | Jnoff, E.,Brookfield, F.,Albrecht, C.,Barker, J.J.,Barker, O.,Beaumont, E.,Bromidge, S.,Brooks, M.,Ceska, T.,Courade, J.P.,Crabbe, T.,Duclos, S.,Fryatt, T.,Jigorel, E.,Kwong, J.,Sands, Z.,Smith, M.A. (deposition date: 2013-06-13, release date: 2014-02-19, Last modification date: 2023-09-20) |
Primary citation | Jnoff, E.,Albrecht, C.,Barker, J.J.,Barker, O.,Beaumont, E.,Bromidge, S.,Brookfield, F.,Brooks, M.,Bubert, C.,Ceska, T.,Corden, V.,Dawson, G.,Duclos, S.,Fryatt, T.,Genicot, C.,Jigorel, E.,Kwong, J.,Maghames, R.,Mushi, I.,Pike, R.,Sands, Z.A.,Smith, M.A.,Stimson, C.C.,Courade, J.P. Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex. Chemmedchem, 9:699-705, 2014 Cited by PubMed: 24504667DOI: 10.1002/cmdc.201300525 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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