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4L7D

Structure of keap1 kelch domain with (1S,2R)-2-{[(1S)-5-methyl-1-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}cyclohexanecarboxylic acid

Summary for 4L7D
Entry DOI10.2210/pdb4l7d/pdb
Related4L7B 4L7C 4N1B
DescriptorKelch-like ECH-associated protein 1, (1S,2R)-2-{[(1S)-5-methyl-1-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}cyclohexanecarboxylic acid, ACETATE ION, ... (4 entities in total)
Functional Keywordsstress sensor, kelch domain, kelch repeat motif, beta-propeller, nrf2, protein-small molecule complex, transcription-inhibitor complex, transcription/inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: Q14145
Total number of polymer chains3
Total formula weight100959.46
Authors
Primary citationJnoff, E.,Albrecht, C.,Barker, J.J.,Barker, O.,Beaumont, E.,Bromidge, S.,Brookfield, F.,Brooks, M.,Bubert, C.,Ceska, T.,Corden, V.,Dawson, G.,Duclos, S.,Fryatt, T.,Genicot, C.,Jigorel, E.,Kwong, J.,Maghames, R.,Mushi, I.,Pike, R.,Sands, Z.A.,Smith, M.A.,Stimson, C.C.,Courade, J.P.
Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex.
Chemmedchem, 9:699-705, 2014
Cited by
PubMed: 24504667
DOI: 10.1002/cmdc.201300525
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.25 Å)
Structure validation

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