4L3V

Crystal structure of delta516-525 human cystathionine beta-synthase

Summary for 4L3V

Entry DOI	10.2210/pdb4l3v/pdb
Related	1JBQ 4L0D 4L27 4L28
Descriptor	Cystathionine beta-synthase, PYRIDOXAL-5'-PHOSPHATE, PROTOPORPHYRIN IX CONTAINING FE (3 entities in total)
Functional Keywords	cbs domain, homocyteine, cysteine biosynthesis, heme, pyridoxal 5'-phosphate, s-adenosylmethionine, transsulfuration pathway, lyase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P35520
Total number of polymer chains	3
Total formula weight	184193.43
Authors	Ereno, J.,Majtan, T.,Oyenarte, I.,Kraus, J.P.,Martinez, L.A. (deposition date: 2013-06-07, release date: 2013-09-18, Last modification date: 2023-09-20)
Primary citation	Ereno-Orbea, J.,Majtan, T.,Oyenarte, I.,Kraus, J.P.,Martinez-Cruz, L.A. Structural basis of regulation and oligomerization of human cystathionine beta-synthase, the central enzyme of transsulfuration. Proc.Natl.Acad.Sci.USA, 110:E3790-E3799, 2013 Cited by PubMed: 24043838 DOI: 10.1073/pnas.1313683110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.628 Å)

Structure validation