4L04
Crystal Structure Analysis of human IDH1 mutants in complex with NADP+ and Ca2+/alpha-Ketoglutarate
Summary for 4L04
Entry DOI | 10.2210/pdb4l04/pdb |
Related | 4KZO 4L03 4L06 |
Descriptor | Isocitrate dehydrogenase [NADP] cytoplasmic, 2-OXOGLUTARIC ACID, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | cytosolic, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : O75874 |
Total number of polymer chains | 6 |
Total formula weight | 294848.17 |
Authors | Concha, N.O.,Smallwood, A.M. (deposition date: 2013-05-30, release date: 2013-07-31, Last modification date: 2024-02-28) |
Primary citation | Rendina, A.R.,Pietrak, B.,Smallwood, A.,Zhao, H.,Qi, H.,Quinn, C.,Adams, N.D.,Concha, N.,Duraiswami, C.,Thrall, S.H.,Sweitzer, S.,Schwartz, B. Mutant IDH1 Enhances the Production of 2-Hydroxyglutarate Due to Its Kinetic Mechanism. Biochemistry, 52:4563-4577, 2013 Cited by PubMed: 23731180DOI: 10.1021/bi400514k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.87 Å) |
Structure validation
Download full validation report