4KXQ
Structure of NAD-dependent protein deacetylase sirtuin-1 (closed state, 1.85 A)
Summary for 4KXQ
Entry DOI | 10.2210/pdb4kxq/pdb |
Descriptor | NAD-dependent protein deacetylase sirtuin-1, ZINC ION, ADENOSINE-5-DIPHOSPHORIBOSE, ... (7 entities in total) |
Functional Keywords | deacetylase, hydrolase |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus, PML body. SirtT1 75 kDa fragment: Cytoplasm: Q96EB6 Q96EB6 |
Total number of polymer chains | 2 |
Total formula weight | 36057.81 |
Authors | Davenport, A.M.,Huber, F.M.,Hoelz, A. (deposition date: 2013-05-27, release date: 2013-10-23, Last modification date: 2024-02-28) |
Primary citation | Davenport, A.M.,Huber, F.M.,Hoelz, A. Structural and Functional Analysis of Human SIRT1. J.Mol.Biol., 426:526-541, 2014 Cited by PubMed: 24120939DOI: 10.1016/j.jmb.2013.10.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.849 Å) |
Structure validation
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