4KWW

The crystal structure of human quinolinic acid phosphoribosyltransferase in complex with its inhibitor phthalic acid

Summary for 4KWW

• Entry DOI: 10.2210/pdb4kww/pdb
• Related: 4KWV
• Descriptor: Nicotinate-nucleotide pyrophosphorylase [carboxylating], PHTHALIC ACID (3 entities in total)
• Functional Keywords: nad, metabolism, type ii phosphoribosyltransferase, quinolinic acid, prpp, brain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 188039.74

Authors

Malik, S.S.,Dimeka, P.N.,Ncube, Z.,Toth, E.A. (deposition date: 2013-05-24, release date: 2013-10-02, Last modification date: 2023-09-20)

• Primary citation: Malik, S.S.,Patterson, D.N.,Ncube, Z.,Toth, E.A.; The crystal structure of human quinolinic acid phosphoribosyltransferase in complex with its inhibitor phthalic acid.; Proteins, 82:405-414, 2014; PubMed: 24038671; DOI: 10.1002/prot.24406

Experimental method

X-RAY DIFFRACTION (2.55 Å)