4KUM
Structure of LSD1-CoREST-Tetrahydrofolate complex
Summary for 4KUM
Entry DOI | 10.2210/pdb4kum/pdb |
Related | 2H94 2HKO 2IW5 2UXX 2V1D |
Descriptor | Lysine-specific histone demethylase 1A, REST corepressor 1, FLAVIN-ADENINE DINUCLEOTIDE, ... (7 entities in total) |
Functional Keywords | histone demethylase, folate binding, chromatin, nucleosomes, oxidoreductase-transcription regulator complex, oxidoreductase/transcription regulator |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: O60341 |
Total number of polymer chains | 2 |
Total formula weight | 101911.04 |
Authors | Luka, Z.,Pakhomova, S.,Loukachevitch, L.V.,Calcutt, M.W.,Newcomer, M.E.,Wagner, C. (deposition date: 2013-05-22, release date: 2014-05-07, Last modification date: 2023-09-20) |
Primary citation | Luka, Z.,Pakhomova, S.,Loukachevitch, L.V.,Calcutt, M.W.,Newcomer, M.E.,Wagner, C. Crystal structure of the histone lysine specific demethylase LSD1 complexed with tetrahydrofolate. Protein Sci., 23:993-998, 2014 Cited by PubMed: 24715612DOI: 10.1002/pro.2469 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.05 Å) |
Structure validation
Download full validation report